looking for a new job....again. What would you do?

[Nikia]

3. I know that you want to leave this career, but if you might be able to change locations

If the supervisor and the hours are the main problem since you mentioned that there were other labs in the area owned by the same company. Maybe the whole company is dysfunctional or maybe they would consider you a problem employee, but maybe other locations with better supervisors have openings that they would let you transfer to.
I left my previous recent employer. I had problems with my supervisor and what she was turning my job into for the last few months there. It is a relatively small company with one location. I was told that my options were to take an entry level production job with a 40% pay cut, put up with it, or leave. If I had the option to transfer to a nearby location with my same pay and job, I would have tried it even if the result might have been the same in the future.